By J. D. Winefordner(eds.)
Caliber size, keep watch over, and development in combinatorial chemistry
Combinatorial chemistry has built swiftly long ago decade, with nice advances made through scientists engaged on research and purification of a giant variety of compounds and the research of polymer-bound compounds. although, ambitious demanding situations lie sooner than modern-day researcher. for instance, high-throughput research and purification applied sciences needs to be additional constructed to make sure combinatorial libraries are "purifiable," and "drugable."
To this finish, research and Purification tools in Combinatorial Chemistry describes a variety of analytical options and platforms for the improvement, validation, qc, purification, and physicochemical checking out of combinatorial libraries. a brand new quantity in Wiley's Chemical research sequence, this article has 4 elements covering:
* a number of techniques to tracking reactions on strong aid and optimizing reactions for library synthesis
* High-throughput analytical tools used to investigate the standard of libraries
* High-throughput purification techniques
* Analytical equipment utilized in post-synthesis and post-purification stages
Drawing from the contributions of revered specialists in combinatorial chemistry, this finished e-book presents insurance of functions of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier rework Infrared (FTIR), micellar electrokinetic chromatography (MEKC) applied sciences, in addition to different analytical techniques.
This eminently important quantity is a necessary addition to the library of scholars and researchers learning or operating in analytical chemistry, combinatorial chemistry, medicinal chemistry, natural chemistry, biotechnology, biochemistry, or biophysics.Content:
Chapter 1 Quantitative research in natural Synthesis with NMR Spectroscopy (pages 1–36): Laura H. Lucas and Cynthia ok. Larive
Chapter 2 19F Gel?Phase NMR Spectroscopy for response tracking and Quantification of Resin Loading (pages 37–51): Joseph M. Salvino
Chapter three the applying of Single?Bead FTIR and colour try out for response tracking and development Block Validation in Combinatorial Library Synthesis (pages 53–69): Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade and Bing Yan
Chapter four HR?MAS NMR research of Compounds connected to Polymer helps (pages 71–86): Meritxell Guino and Yolanda R. de Miguel
Chapter five Multivariate instruments for Real?Time tracking and Optimization of Combinatorial fabrics and approach stipulations (pages 87–123): Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon, William P. Flanagan and Oltea P. Siclovan
Chapter 6 Mass Spectrometry and Soluble Polymeric aid (pages 125–135): Christine Enjalbal, Frederic Lamaty, Jean Martinez and Jean?Louis Aubagnac
Chapter 7 High?Throughput NMR recommendations for Combinatorial Chemical Library research (pages 137–173): Ting Hou and Daniel Raftery
Chapter eight Micellar Electrokinetic Chromatography as a device for Combinatorial Chemistry research: idea and purposes (pages 175–208): Peter J. Simms
Chapter nine Characterization of Split?Pool Encoded Combinatorial Libraries (pages 209–252): Jing Jim Zhang and William L. Fitch
Chapter 10 recommendations and techniques for Purifying natural Compounds and Combinatorial Libraries (pages 253–280): Jiang Zhao, Lu Zhang and Bing Yan
Chapter eleven High?Throughput Purification: Triage and Optimization (pages 281–306): Jill Hochlowski
Chapter 12 Parallel HPLC in High?Throughput research and Purification (pages 307–320): Ralf God and Holger Gumm
Chapter thirteen natural Compound balance in huge, various Pharmaceutical Screening Collections (pages 321–350): Kenneth L. Morand and Xueheng Cheng
Chapter 14 Quartz Crystal Microbalance in Biomolecular attractiveness (pages 351–368): Ming?Chung Tseng, I?Nan Chang and Yen?Ho Chu
Chapter 15 High?Throughput Physicochemical Profiling: power and boundaries (pages 369–406): Bernard Faller
Chapter sixteen Solubility within the layout of Combinatorial Libraries (pages 407–434): Christopher Lipinski
Chapter 17 High?Throughput selection of Log D Values through LC/MS technique (pages 435–455): Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt and James J. Bao
Read or Download Analysis and Purification Methods in Combinatorial Chemistry, Volume 163 PDF
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